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pneumococcal conjugate vaccine : ウィキペディア英語版
pneumococcal conjugate vaccine

Pneumococcal conjugate vaccine (PCV) is a pneumococcal vaccine and a conjugate vaccine used to protect infants, young children, and adults against disease caused by the bacterium ''Streptococcus pneumoniae'' (the pneumococcus). There are currently three types of PCV available on the global market, which go by the brand names: Prevnar (called Prevenar in some countries), Synflorix and Prevnar 13.
*Prevnar (PCV7) is a ''hepta''valent vaccine, meaning that it contains the cell capsule sugars of seven serotypes of the bacteria ''S. pneumoniae'' (4, 6B, 9V, 14, 18C, 19F and 23F) , conjugated with diphtheria proteins. It was manufactured by Wyeth (which has since been acquired by Pfizer).〔(【引用サイトリンク】title=Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) )〕 In the United States, vaccination with Prevnar is recommended for all children younger than 2 years, and for unvaccinated children between 24 and 59 months old who are at high risk for pneumococcal infections.
*Synflorix (PCV10) is produced by GlaxoSmithKline. It is a ''deca''valent vaccine, meaning that it contains ten serotypes of pneumococcus (1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F) which are conjugated to a carrier protein. Synflorix received a positive opinion from the European Medicines Agency for use in the European Union in January 2009〔(EMEA Document )〕 and GSK received European Commission authorization to market Synflorix in March 2009.〔(GSK Release )〕
*Prevnar 13 (PCV13) is produced by Pfizer. It is a tridecavalent vaccine, meaning that it contains thirteen serotypes of pneumococcus (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) which are conjugated to diphtheria carrier protein. Prevnar 13 was approved by the U.S. Food and Drug Administration on February 24, 2010.〔http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm201758.htm〕 After waiting for the outcome of a trial underway in the Netherlands, the Centers for Disease Control and Prevention (CDC) recommended the vaccine for adults over age 65 in August, 2014.
==Production technique==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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